TBTL (Too Beautiful To Live) is a wonderful (somewhat mindless) podcast. I heard about this podcast when the host, Luke Burbank contributed a piece to This American Life.
TBTL started out as a talk radio show in Seattle, but was canceled. Now it lives on in the internet. The scrappy crew of the podcast includes Luke, Jen, and sometimes the lovable and zany Sean.
The show is a weird mix of quaint cult hit and culture commentary. It is a daily show, so there are a lot of hours to fill. Luke has enough connections that there are often fairly famous guests, but his self loathing keeps the show from getting too big of a head.
If you are looking for a lot of hours of entertainment I suggest you give TBTL a listen.